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TRAF-STOP inhibitor 6877002
CAS No. 433249-94-6
TRAF-STOP inhibitor 6877002( —— )
Catalog No. M33523 CAS No. 433249-94-6
TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 34 | Get Quote |
|
| 25MG | 73 | Get Quote |
|
| 50MG | 133 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTRAF-STOP inhibitor 6877002
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NoteResearch use only, not for human use.
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Brief DescriptionTRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction.
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DescriptionTRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number433249-94-6
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Formula Weight251.32
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Molecular FormulaC17H17NO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (397.90 mM; Ultrasonic )
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SMILESCc1ccc(C)c(N\C=C\C(=O)c2ccccc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Seijkens TTP, et al. Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542.?
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